N-methyl-4-chloropiperidine is an important pharmaceutical intermediate for the synthesis of antihistamines such as ketotifen, phenylthiazide and loratadine.
Chinese name N- methyl -4- chlorperidol
Foreign name 4-Chloro-N-methylpiperidine
Molecular formula C6H12CIN
Molecular weight 133.62
CAS No 5570-77-4
4-chloro-1-methyl piperidine; 4-chloro-N-methyl piperidine; N-methyl-4-chloropiperidine; 1-methyl-4-chloropiperidine; 4-chloro-1-methyl piperidine; N-methyl-4-chloropiperidine or 1-methyl-4-chloropiperidine
Melting point 160-165 degree C
Flash point 48 C
Boiling point: 160-162 degrees C, 47-48 (1.3KPa)
Appearance (Appearance): colorless transparent oily liquid.
Dangerous goods signs: Xi, C
Danger category code: 10-34
Safety instructions: 22-24/25-45-36/37/39-26
The product can be prepared by catalytic hydrogenation of 1-methyl-4-piperidone to 1-methyl-4-hydroxypropidine and then by chlorination of thionyl chloride.
Important pharmaceutical intermediates for the synthesis of antihistamine drugs such as ketotifen, thticotifen, loratadine, etc.