Abemaciclib Mesylate LY2835219 CAS 1231929-97-7

Payment Type: L/C,T/T,Paypal
Incoterm: FOB,CIF
Min. Order: 10 Gram
Delivery Time: 3 Days

Basic Info

Model No.: CAS 1231929-97-7

Additional Info

Packaging: 10g 100g 1kg

Productivity: 100 kg/month

Brand: cy

Transportation: Ocean,Land,Air

Place of Origin: China

Supply Ability: 50kg

Certificate: ISO 9001, GMP

Port: QINGDAO,SHANGHAI

Product Description

Abemaciclib, also known as LY2835219, is orally available cyclin-dependent kinase (CDK) inhibitor that targets the CDK4 (cyclin D1) and CDK6 (cyclin D3) cell cycle pathway, with potential antineoplastic activity. LY2835219 inhibits CDK4 and CDK6 with low nanomolar potency. LY2835219 specifically inhibits CDK4 and 6, thereby inhibiting retinoblastoma (Rb) protein phosphorylation in early G1. Inhibition of Rb phosphorylation prevents CDK-mediated G1-S phase transition, thereby arresting the cell cycle in the G1 phase, suppressing DNA synthesis and inhibiting cancer cell growth.


Item

Specification 

Specific rotation

+39.5 to +41.5° 

State of solution(transmittance)

Clear 98.0% min.

Chloride[cl]

0.020% max. 

Ammonium [NH4]

0.02% max. 

Sulfate[SO4]

0.020% max

Iron[Fe]

10ppm max.

Heavy metals [Pb]

10ppm max

Arsenic[As2O3]

1ppm max

Other amino acids

Chromatographically not detectable

Loss on drying

0.20% max. 

Residue on ignition[sulfated]

0.10% max.

Assay

99.0% min


Contact Information

CONTACT US

Shandong Chenyi Environmental Protection Technology Co.,Ltd

Contact Person: Jerry

Phone:86-0531-18560179988

Fax:

Address: No.215 Beiyuan Main street,tianqiao District,Jinan,Shandong

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