antineoplastic antibiotic raw material AP24534 Ponatinib CAS 943319-70-8

Payment Type: L/C,T/T,Paypal
Incoterm: FOB,CIF
Min. Order: 10 Gram
Delivery Time: 3 Days

Basic Info

Model No.: CAS 943319-70-8

Additional Info

Packaging: 10g 100g 1kg

Productivity: 30 T/year

Brand: cy

Transportation: Ocean,Land,Air

Place of Origin: China

Supply Ability: 10 T

Certificate: ISO 9001, GMP

Port: QINGDAO,SHANGHAI

Product Description

Ponatinib (AP 24534) is a small molecule, multi-target kinase inhibitor known to potently inhibit Bcr-Abl (the fusion protein of Bcr and c-Abl), Flk-1(VEGFR2) and FGFR. It also exhibits inhibitory activity against PDGFRα, c-Src and c-Kit. AP 24534 inhibits the proliferation of mutant FLT3-positive cells (IC50 of 13 nM), which inhibits mutant FLT3 phosphorylation (IC50 of 1 nM) and the proliferation of Bcr-Abl1 T315I-positive Ba/F3 cells with an IC50 of 8 nM.


Ponatinib is an orally bioavailable multitargeted receptor tyrosine kinase (RTK) inhibitor with potential antiangiogenic and antineoplastic activities. Multitargeted tyrosine kinase inhibitor AP24534 inhibits unmutated and all mutated forms of Bcr-Abl, including T315I, the highly drug therapy-resistant missense mutation of Bcr-Abl. This agent also inhibits other tyrosine kinases including those associated with vascular endothelial growth factor receptors (VEGFRs) and fibroblast growth factor receptors (FGFRs); in addition, it inhibits the tyrosine kinase receptor TIE2 and FMS-related tyrosine kinase receptor-3 (Flt3).


COA


Item

Standard

Test Results

Identification

A.H-NMR:Comply with the structure

Complies

B.LC-MS:Comply with the structure

Complies

C.The IR spectrum of sample should be identical with that of reference standard;

Complies

D.HPLC-ESI-MS

Complies

The retention time of the major peak in the chromatogram of the Assay preparation corresponds to that in the chromatogram of the Standard preparation, as obtained in the Assay.

Heavy metals

≤10 ppm

<10ppm

Water

≤1.0%

0.10%

Sulphated ash

≤0.5%, determined on 1.0 g.

0.01%

Related substances

Unspecified impurities: for each impurity

≤0.10%

<0.10%

Total Impurity

≤0.5%

0.18%

Purity

≥99.0%

99.70%

Assay

99.0%~101.0% (anhydrous substance).

99.80%

Storage

Preserve in well-closed, light-resistant and airtight containers.

Complies



Contact Information

CONTACT US

Shandong Chenyi Environmental Protection Technology Co.,Ltd

Contact Person: Jerry

Phone:86-0531-18560179988

Fax:

Address: No.215 Beiyuan Main street,tianqiao District,Jinan,Shandong

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