Antineoplastic USP Grade APIs Daunorubicin Hydrochloride with CAS 23541-50-6

Payment Type: L/C,T/T,Paypal
Incoterm: FOB,CIF
Min. Order: 10 Gram
Delivery Time: 5 Days

Basic Info

Model No.: CAS 23541-50-6

Additional Info

Packaging: 10g 100g 1kg

Productivity: 100 kg/month

Brand: cy

Transportation: Ocean,Land,Air

Place of Origin: China

Supply Ability: 10 kg

Certificate: ISO 9001,GMP

Port: QINGDAO,SHANGHAI

Product Description

Antineoplastic USP Grade APIs Daunorubicin Hydrochloride  with CAS: 23541-50-6


English name:Daunorubicin Hydrochloride

Specification: 99%

CAS NO.:23541-50-6

Appearance: Red to Orange Red crystalline powder



This product is the first generation of anthracycline antitumor antibiotics. The mechanism resembles doxorubicin. As a cycle non-specific chemotherapy drugs, daunorubicin spectrum anti-tumor doxorubicin far more narrow, for Solid Tumors great as doxorubicin and epirubicin. 

Daunorubicin is a clinical first-line anti-cancer drug, is widely used in the clinical treatment of cancer. However, in human liver widespread carbonyl reductase 1 daunorubicin can be converted into a new alcohol metabolite daunorubicin alcohol. This new generation of alcohol metabolites not only lower than the anti-tumor activity of daunorubicin, but also toxic to the heart, resulting in myocardial cell injury.

The metabolic characteristics of daunorubicin greatly limits its clinical application. If we can find a carbonyl reductase inhibitors, not only can improve the clinical efficacy of daunorubicin and other anthracycline anticancer drugs, but also can reduce the toxic side effects of daunorubicin.



Certificate Of Analysis

 

ITEM

SPECEFICATIONS

RESULTS

Appearance

Description

Red to Orange Red crystalline powder

Conforms

Identification

IR Spectrum

Conforms to reference standard

Conforms

HPLC

Conforms to reference standard

Conforms

pH

4.5~6.5

5.2

Heavy metals

20 ppm max

Conforms

Water

2.0%max

0.99%

Related substance

Any other impurity

1.5% max

0.84%

Total impurities

3.0% max

1.66%

Solvent residue

Ethanol

0.5% max

0.15%

Butanol

1.0% max

0.22%

Chloroform

0.006% max

Not detected

Acetone

0.5% max

Not detected

Carbinol

0.5% max

Not detected

Assay (by HPLC)

90~102%  calculated on anhydrous and solvent-free basis

94.77%

Conclusion

Comply with in-house standard



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