Endothelin Antagonists Bosentan CAS 147536-97-8

Payment Type: L/C,T/T,Paypal
Incoterm: FOB,CIF
Min. Order: 10 Gram
Delivery Time: 3 Days

Basic Info

Model No.: CAS 147536-97-8

Additional Info

Packaging: 10g 100g 1kg

Productivity: 100 kg/month

Brand: cy

Transportation: Ocean,Land,Air

Place of Origin: China

Supply Ability: 50kg

Certificate: ISO 9001, GMP

Port: QINGDAO,SHANGHAI

Product Description





English name: Bosentan

Synonyms: Benzenesulfonamide,4-(1,1-dimethylethyl)-N-[6-(2-hydroxyethoxy)-5-(2-methoxyphenoxy)[2,2'-bipyrimidin]-4-yl]-,monohydrate (9CI)

Specification: 98%

CAS NO.:147536-97-8

Appearance: white powder

Molecular weight: 551.61

Molecular formula: C27H29N5O6S

Boiling point: 742.3 ° C at 760 mmHg Flash Point: 402.8 ° C Vapor Pressure: 3.84E-23mmHg at 25 ° C

Bosentan is a dual endothelin receptor antagonist used in the treatment  of pulmonary artery hypertension (PAH). It is licensed in the United States,theEuropean Union and other countries by Actelion Pharmaceuticals for the management of PAH under the trade name Tracleer.


Appliciation:



1.Bosentan is used to treat people with moderate pulmonary arterial hypertension and to reduce the number of digital ulcers - open wounds on especially on fingertips and less commonly the knuckles - in people with systemic scleroderma.
2.Bosentan causes harm to fetuses and pregnant women must not take it, and women must not become pregnant while taking it (Pregnancy Category X). It may render hormonal contraceptives ineffective so other forms of birth control must be used.

3.In the US it is only available from doctors who follow an FDA-mandated risk evaluation and mitigation strategy (REMS) with respect to risks to fetuses and its risks of causing liver damage. The doctor must document a negative pregnancy test for women before prescribing the drug, counsel about contraception, and give regular pregnancy tests.



Contact Information

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Shandong Chenyi Environmental Protection Technology Co.,Ltd

Contact Person: Jerry

Phone:86-0531-18560179988

Fax:

Address: No.215 Beiyuan Main street,tianqiao District,Jinan,Shandong

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