MK-1775 High Purity AZD1775 Adavosertib CAS 955365-80-7​

Payment Type: L/C,T/T,Paypal
Incoterm: FOB,CIF
Min. Order: 10 Gram
Delivery Time: 3 Days

Basic Info

Model No.: CAS 955365-80-7​

Additional Info

Packaging: 10g 100g 1kg

Productivity: 50 kg/month

Brand: cy

Transportation: Ocean,Land,Air

Place of Origin: China

Supply Ability: 50kg

Certificate: ISO 9001, GMP

Port: QINGDAO,SHANGHAI

Product Description


MK-1775



Cas 955365-80-7


Appearance : white powder


Purity : 99% min




More information of Fresh stock Cas 955365-80-7



Molecular formula: C27H32N8O2


Molecular weight: 500.59500

Exact mass: 500.26500

PSA: 104.34000

LogP: 2.96190

Density: 1.293 g / cm3

Boiling point: 723.804ºC at 760 mmHg

Flash point: 391.543ºC




Application of Fresh stock Cas 955365-80-7


MK 1775 is used in biological studies for the abrogation of G2/M checkpoint through WEE1 inhibition in combination with chemotherapy as a promising therapeutic approach for mesothelioma.

Anticancer  APIS


MK-1775, also known as adavosertib, AZD-1775, is a WEE1 inhibitor, is also a small molecule inhibitor of the tyrosine kinase WEE1 with potential antineoplastic sensitizing activity. MK-1775 selectively targets and inhibits WEE1, a tyrosine kinase that phosphorylates cyclin-dependent kinase 1 (CDC2) to inactivate the CDC2/cyclin B complex. Inhibition of WEE1 activity prevents the phosphorylation of CDC2 and impairs the G2 DNA damage checkpoint. This may lead to apoptosis upon treatment with DNA damaging chemotherapeutic agents.





Contact Information

CONTACT US

Shandong Chenyi Environmental Protection Technology Co.,Ltd

Contact Person: Jerry

Phone:86-0531-18560179988

Fax:

Address: No.215 Beiyuan Main street,tianqiao District,Jinan,Shandong

Full name Contact Phone Content
点击刷新验证码