MK-1775 High Purity AZD1775 Adavosertib CAS 955365-80-7​

Payment Type: L/C,T/T,Paypal
Incoterm: FOB,CIF
Min. Order: 10 Gram
Delivery Time: 3 Days

Basic Info

Model No.: CAS 955365-80-7​

Additional Info

Packaging: 10g 100g 1kg

Productivity: 50 kg/month

Brand: cy

Transportation: Ocean,Land,Air

Place of Origin: China

Supply Ability: 50kg

Certificate: ISO 9001, GMP


Product Description


Cas 955365-80-7

Appearance : white powder

Purity : 99% min

More information of Fresh stock Cas 955365-80-7

Molecular formula: C27H32N8O2

Molecular weight: 500.59500

Exact mass: 500.26500

PSA: 104.34000

LogP: 2.96190

Density: 1.293 g / cm3

Boiling point: 723.804ºC at 760 mmHg

Flash point: 391.543ºC

Application of Fresh stock Cas 955365-80-7

MK 1775 is used in biological studies for the abrogation of G2/M checkpoint through WEE1 inhibition in combination with chemotherapy as a promising therapeutic approach for mesothelioma.

Anticancer  APIS

MK-1775, also known as adavosertib, AZD-1775, is a WEE1 inhibitor, is also a small molecule inhibitor of the tyrosine kinase WEE1 with potential antineoplastic sensitizing activity. MK-1775 selectively targets and inhibits WEE1, a tyrosine kinase that phosphorylates cyclin-dependent kinase 1 (CDC2) to inactivate the CDC2/cyclin B complex. Inhibition of WEE1 activity prevents the phosphorylation of CDC2 and impairs the G2 DNA damage checkpoint. This may lead to apoptosis upon treatment with DNA damaging chemotherapeutic agents.

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