Place of Origin: CHINA
[density]: 1.3±0.1 g/cm3
[ Boiling point ]: 267oC
[melting point]: 147oC
[ Molecular formula ]: C3H6N2O2
[Molecular Weight]: 102.092
[Exact quality ]: 102.042931
[ PSA ]: 64.35000
[ LogP ]: -1.84
[CAS No.]:68-41-7[ Appearance traits ]: White to off-white powder
This product should be sealed in a cool dry place away from light.
D-cycloserine is a broad-spectrum antibiotic of the polypeptide produced by Streptomyces lavendulae and S. orchidaces or chemically synthesized. It is white crystal, strong hygroscopicity, soluble in water, soluble in lower alcohol, acetone and dioxane, insoluble in chloroform and petroleum ether; stable in alkaline solution, in acidic and neutral solution Decompose quickly. Cycloserine has a broad antibacterial spectrum. In addition to Mycobacterium tuberculosis, it also inhibits most Gram-positive and negative bacteria, Rickettsia and certain protozoa. For streptomycin, zirconia, and amino-sodium M. tuberculosis resistant to acid, isoniazid, pyrazinamide, etc. also has a role. Cycloserine and isoniazid have a mild synergistic effect on Mycobacterium tuberculosis H37RV, and neither synergistic nor antagonism with streptomycin. This product is a bacteriostatic agent, increasing the dose or prolonging the time of action with bacteria, and does not cause bactericidal action.
The mechanism of the antibacterial action of D-cycloserine is to inhibit the biosynthesis of cell wall peptidoglycan, which is a structural analog of D-alanine, which can competitively inhibit the synthesis of peptidoglycan with D-alanine. Two important enzymes - alanine racemase and D-alanyl-D-alanine synthetase. Its ability to resist Mycobacterium tuberculosis is weak, only 1/10 to 1/20 of streptomycin. The advantage is that it is effective against the resistant strain of the bacteria, and it is not easy to develop resistance to it. This product can be combined with other anti-tuberculosis drugs to treat tuberculosis caused by drug-resistant M. tuberculosis.
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