Research API Poziotinib High quality CAS 1092364-38-9 Poziotinib or HM781-36B

Payment Type: L/C,T/T,Paypal
Incoterm: FOB,CIF
Min. Order: 1 Kilogram
Delivery Time: 3 Days

Basic Info

Model No.: CAS 1092364-38-9

Appearance: White Crystalline Powder

CAS: 57149-07-2

Additional Info

Packaging: 1kg 20kg 200kg

Productivity: 30 T/year

Brand: cy

Transportation: Ocean,Land,Air

Place of Origin: China

Supply Ability: 10 T

Certificate: ISO 9001, GMP

Port: QINGDAO,SHANGHAI

Product Description


Name: Poziotinib


Brand Nutrabiotech


Poziotinib (HM781-36B), purity > 98%

CAS: 1092364-38-9

Chemical Formula: C23H21Cl2FN4O3

Exact Mass: 490.09747

Molecular Weight: 491.34

Elemental Analysis: C, 56.22; H, 4.31; Cl, 14.43; F, 3.87; N, 11.40; O, 9.77


Poziotinib (NOV120101, HM781-36B). It is built on an anilino-quinoline scaffold and inhibits the epidermal growth factor receptors EGRF, HER2/neu, and Her 4 and binds covalently to its targets.

NMR of Poziotinib


HPLC of Poziotinib



Poziotinib , also known as HM781-36B and NOV120101, is an orally bioavailable, quinazoline-based pan epidermal growth factor receptor (EGFR or HER) inhibitor with potential antineoplastic activity. HM781-36B irreversibly inhibits EGFR (HER1 or ErbB1), including EGFR mutants, HER2, and HER4, thereby inhibiting the proliferation of tumor cells that overexpress these receptors. EGFRs, cell surface receptor tyrosine kinases, are often upregulated in a variety of cancer cell types and play key roles in cellular proliferation and survival.
poziotinib

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